London, May 10 (IANS) In a finding that could change the way the most common form of stroke is treated globally, researchers have shown that modified dosage of a clot-busting drug can reduce risk of serious bleeding in the brain and improve survival rates.
Intravenous rtPA (or alteplase) is given to people suffering acute ischaemic stroke and works by breaking up clots blocking the flow of blood to the brain.
However, it can cause serious bleeding in the brain in around five per cent of cases, with many of these proving fatal.
Compared to standard dose (0.9mg/kg body weight), the lower dose (0.6mg/kg) of rtPA reduced rates of serious bleeding in the brain, known as intracerebral haemorrhage (ICH), by two thirds, showed the results of the trial of more than 3,000 patients in 100 hospitals worldwide.
"Most patients who have a major stroke want to know they will survive but without being seriously dependent on their family. We have shown this to be the case with the lower dose of the drug,” said one of the researchers Tom Robinson, professor at University of Leicester in Britain.
The findings were published in the New England Journal of Medicine.
"At the moment you could have a stroke but end up dying from a bleed in the brain. It's largely unpredictable as to who will respond and who is at risk with rtPA,” lead author of the study Craig Anderson, professor at Sydney Medical School, University of Sydney in Australia.
"What we have shown is that if we reduce the dose level, we maintain most of the clot busting benefits of the higher dose but with significantly less major bleeds and improved survival rates. On a global scale, this approach could save the lives of many tens of thousands of people,” Anderson noted.
Rome, May 6 (IANS) World food prices rose slightly in April, marking a third consecutive monthly increase after four years of decline, but they remained almost 10 percent lower than a year earlier, the UN food agency said.
Washington, May 9 (IANS) In a move that could immensely benefit private space technology companies, NASA has released 56 formerly patented agency technologies into the public domain, making its government-developed technologies freely available for unrestricted commercial use.
London, May 8 (IANS) A spurt in number of billionaires and increasing wealth creation by any means have made India rank ninth among the crony capitalist countries, said a study in "The Economist" latest issue.
Beijing, May 8 (IANS) China's exports rose 4.1 percent year on year in April while imports dipped 5.7 percent, customs data showed on Sunday.
It led to a monthly trade surplus of 298 billion yuan ($45 billion), up from March's 194.6 billion yuan, according to figures from the General Administration of Customs, reports
New York, May 6 (IANS) Although India managed to counter a steep decline in its vulture population in mid-1990s, these efficient scavengers are in danger of disappearing in many parts of the world primarily due to the presence of toxins in the carrion they consume.
Poisoning is the greatest extinction risk facing vultures, and impacts 88 percent of threatened vulture species, the study said.
Now, the center of the vulture crisis is in sub-Saharan Africa, the researchers noted.
In the mid-1990s India experienced a precipitous vulture decline, with more than 95 percent of vultures disappearing by the early 2000s.
"That was a massive collapse that led a lot of people to really focus more attention on vultures," said one of the researchers Evan Buechley from University of Utah in the US.
The cause was eventually traced to diclofenac, a veterinary anti-inflammatory drug that relieved pain in cattle, but proved highly toxic to vultures.
Hundreds of vultures would flock to each cattle carcass. And if the cow had recently been treated with diclofenac, hundreds of vultures would die.
Because of this highly gregarious feeding behaviour, less than one percent of cattle carcasses contaminated with diclofenac could account for the steep vulture decline.
Fortunately, international cooperation led to a total ban on veterinary diclofenac use.
The numbers of vultures have stabilised, and are now showing signs of slowly increasing, Buechley said.
Losses of vultures can allow other scavengers to flourish, Buechley pointed out in a report published in the journa Biological Conservation.
For example, following the decline of vultures, India experienced a strong uptick in feral dogs --by an estimated seven million.
The increase in dogs, potentially feeding on disease-ridden carcasses, is thought to have at least partially caused the rabies outbreak that was estimated to have killed 48,000 people from 1992-2006 in India -- deaths that may have been avoided if not for the disappearance of vultures.
Members of the Parsi sect of Zoroastrianism experienced a different impact. For thousands of years, the Parsi people have placed their dead on exposed mountaintops or tall towers for vultures to consume. The practice is called "sky burial."
But with few vultures and unable to properly handle their dead, the Parsis experienced a crisis within the faith.
Some constructed captive vulture aviaries. Others talked about desiccating bodies using focused solar mirrors. The Parsis' plight exemplifies the vultures' role in south Asian society -- and the various impacts if the vultures are not there.
Although the vulture crisis in Africa is ongoing, the researchers can predict what the outcome will be, based on previous experiences in India.
Crows, gulls, rats and dogs will boom. And the rabies outbreak in India may just be a prologue, because several sub-Saharan Africa countries already have the highest per-capita rabies infection rates in the world, the researchers noted.
London, May 8 (IANS) Researchers have developed a set of algorithms that could help teach computers to process and understand human languages better.
While mastering natural language is easier for humans, it is something that computers have not yet been able to achieve. Humans understand language through a variety of
New York, May 6 (IANS) Researchers have developed a miniature camera that can be mounted onto the eyeglasses of people who are legally blind -- vision with 20/200 or worse in the better eye -- and dramatically improve their ability to read an email or a newspaper article.
Made using optical character-recognition technology, the artificial vision device can be easily mounted onto the eyeglasses and works either by pointing at an item, tapping on it, or pressing a trigger button.
A wire attaches the device to a small pack containing its battery and computer. It recognises text and reads it to the user using an earpiece that transmits sound, and can also be programmed to recognise faces and commercial products.
The camera device offers hope to patients with age-related macular degeneration -- leading cause of permanent impairment of reading and fine or close-up vision in the elderly -- who are beyond medical or surgical therapy for the condition, researchers said.
“The device offers new hope for the large and growing number of individuals with age-related macular degeneration or advanced-stage glaucoma, two of the leading causes of vision loss among the elderly,” said one of the researchers Mark Mannis, professor at University of California in the US.
The device, which can be carried, fit into a pocket or attached to a belt, can also help older adults who are struggling with vision loss to better perform daily activities and could potentially bring greater independence, the researchers added in the paper published online in the journal JAMA Ophthalmology.
The team conducted a pilot study and analysed 12 participants with low vision, six men and six women, with an average age of 62.
Using the device, the study participants were significantly better able to perform activities of daily living.
"Our results show that it can be a very useful aid for patients with low vision in performing activities of daily living, and increase their functional independence," said another researcher Elad Moisseiev.