Knowledge Update | Horizon University UAE – Essential Insights

Moscow, April 6 (IANS) A new study by an international team of scientists has revealed conditions under which a body produces more superoxide -- a dangerous form of oxygen with the capability to destruct DNA.

Human mutations in a gene encoding the DHTKD1 protein result in a range of neurological disturbances. On molecular level, the mutations cause accumulation of the reactive oxygen species (ROS) and degradation products of lysine and tryptophan, said the study published recently in the journal Free Radical Biology and Medicine. 

The structure of the DHTKD1 protein is similar to an enzyme, 2-oxoglutarate dehydrogenase, which is able to produce superoxide. 

According to the researcher, a cell combats the "poisonous" forms of oxygen with a help of antioxidants, and antioxidant defence system proteins.

But disturbed metabolism may cause a shortage of amino acids (the bricks for building proteins) lysine and tryptophan which may result into physical, neurologic and mental malfunctions, and even lead to death. 

Those amino acids belong to irreplaceable and cannot be produced from other substances in human body, so they should come from food, the researchers noted.

According to the study, 2-aminoadipate and 2-oxoadipate are the degradation products of lysine, tryptophan and hydroxylysine.

Scientists found the connection between aciduria (increased acidity of urine, showing serious malfunction in metabolism) in patients with increased content of 2-aminoadipate and 2-oxoadipate and gene mutations in the DHTKD1 protein. 

That confirmed an earlier hypothesis that an enzyme, encoded by DHTKD1, oxidises 2-oxoadipate.

The DHTKD1 protein does not belong to central metabolism and is produced in higher quantities in liver and kidney cells where lysine and tryptophan are more actively degraded. In humans it is degraded in skeletal muscles. 

The study found that both the down- and up-regulation of the DHTKD1 expression increased the level of reactive and dangerous forms of oxygen.​

​Seoul, April 5 (IANS) South Korea's top automaker Hyundai Motor and its affiliate Kia Motors on Tuesday announced a plan to develop artificial intelligence (AI)-based, internet-connected car to create a new future lifestyle with a "driving, high-performing computer". The driving computer means a car will become a high-performing computer itself as the car, to be developed by Hyundai and Kia, will self-drive based on AI and connect to electronic devices while driving based on internet connectivity, Xinhua cited a joint statement as saying. The main concept of the project is a "hyper-connected and intelligent car", which means an interaction between cars home as well as home and office in addition to AI-based self-driving. To achieve the goal, the automakers will focus on four major themes, intelligent remote-controlling support service, perfect self-driving, smart traffic and mobility hub. The remote-controlling support service aims to check and examine cars on a real-time basis to detect potential emergency situations in advance. The perfect self-driving is aimed at creating a safe-driving environment by exchanging information with everything, including cars and roads. Smart traffic is designed to reduce time and energy by analysing traffic conditions and finding an optimised route of getting to a destination. Mobility hub means a car becomes a hub to link internet-connected devices. The hyper-connected and intelligent car also aims to enable smartphone functions to be reproduced within a car. The smart home connection service targets a remote control of home appliances within the car.​

​New York, April 6 (IANS) Chronic lack of sleep and irregular sleep-wake cycles that disturb the biological cycle are likely to risk the onset of Parkinson's disease as well as worsen the disease, warns a new study.

The animals-based study showed that the disturbances in the circadian rhythm -- the roughly 24-hour biological cycle of humans daily exposure to long periods of light with brief exposure to dark may also dramatically worsen the motor and learning deficits brought on by the disease.

"Many think that sleep disturbances are secondary to Parkinson's disease. But circadian rhythm disturbances are increasingly reported before the onset of Parkinson's, suggesting that they could be risk factors," said Domenico Pratico, professor at LKSOM in the US.

Further, the researchers observed significant reductions in neurons in substantia nigra -- a brain region that produce dopamine, the loss of which is a major molecular feature of Parkinson's disease. 

"Cells normally die in that region of the brain, but our study shows that circadian rhythm disturbance accelerates cell death there," Pratico added.

In addition, cells known as microglia, which normally protect neurons, were superactive in circadian-disrupted MPTP-treated mice. 

The overactivation of microglia can actually worsen neuroinflammation and potentially speed the progression of Parkinson's disease.

The findings are detailed online in the journal Molecular Psychiatry.

The team investigated the role of altered circadian rhythm using a well-established mouse model of Parkinson's disease, in which treatment with MPTP, a neurotoxin that reproduces aspects of the disease in mice. 

Assessments of movement and behaviour showed that all mice treated with MPTP developed Parkinson's disease, but animals with altered circadian rhythm experienced significant learning impairments. 

They also exhibited severe motor deficits, with drastic reductions in motor coordination and motor learning skills - far worse than the deficits observed in MPTP-treated mice with normal circadian rhythm.​

London, April 5 (IANS) In older adults, especially women, higher dietary calcium intake may lower the risk of cardiovascular disease, but not of stroke and fracture, new research suggests.

"The role of dietary calcium intake in cardiovascular disease, stroke and fracture is controversial. We aimed to evaluate whether high dietary calcium intake increases the risk of CVD, stroke and fracture in a population with low calcium intake," said lead study author Sung Hye Kong from Seoul National University Hospital in Seoul, South Korea.

Researchers conducted their study among individuals in Korea's ongoing prospective community-based Ansung and Ansan Cohort Study that began in 2001.

The authors performed their analyses in 2,199 men and 2,704 women over 50 years of age without previous cardiovascular disease and stroke.

The participants in the study reported their dietary food intake in periodic food frequency questionnaires.

Cardiovascular disease, stroke and fractures were recorded during interviews and examinations every two years.

The findings suggest, in older women in this population with low dietary calcium intake, higher dietary calcium intake was significantly associated with decreased risk of cardiovascular disease, but not significantly associated with risk of stroke and fracture.​

​London, April 6 (IANS) The salt levels of oceans on distant Earth-like planets could have a major effect on their climates and may provide more habitable conditions for alien life, says a study involving an Indian-origin scientist.

"The number of planets being discovered outside our solar system is rapidly increasing. Our research helps to answer whether or not these planets could sustain alien life," said David Stevens from Britain's University of East Anglia (UEA). 

"Oceans play a vital role in sustaining life and also have an immense capacity to control climate. But previous studies on ocean circulation on other planets have made the assumption that fundamental ocean properties - such as the salinity and depth of water - would be similar to that on Earth," he added.

Stevens' team used computer models of ocean circulation on exoplanets to see what would happen when their oceans had different salinity levels to Earth. 

The study, published recently in the Proceedings of the National Academy of Sciences, considered oceans with very low salinity (similar to freshwater), salinity similar to the average value of Earth's oceans, and high salinity (similar levels to the Dead Sea).

"On Earth, we have a circulation where warm water moves towards the poles at the surface, before being cooled, then sinking at high latitudes and travelling towards the equator at depth," said Manoj Joshi from UEA's School of Environmental Sciences.

"Our research shows that oceans on other planets with a much higher salinity could circulate in the opposite direction - with polar water flowing towards the equator at the surface, sinking in the tropics and travelling back towards the poles at depth. We also found a similar pattern emerging for freshwater oceans," Joshi added.

"These circulation patterns are the opposite of what happens on Earth, and would result in a dramatic warming in the polar regions. Such a circulation scenario might extend the planet's range of habitability," he noted.

The study assumes significance as until recently computer simulations of habitable climates on Earth-like planets have mainly focused on their atmospheres. But studying their oceans is vital for understanding climate stability and habitability -- as on our own Earth.​

​Tokyo, April 5 (IANS) Japanese carmaker Toyota on Tuesday announced it will collaborate with US tech giant Microsoft to improve services for cars connected to the internet in the future.

New York, March 31 (IANS) Do you become the "grammar police?" when reading emails? If yes, you could be an introvert, suggests new research that established a link between personality traits and reaction of typos and grammatical errors in emails.

Extroverted people are likely to overlook typos and grammatical errors that would cause introverted people to judge the person who makes such errors more negatively, said the study published in the journal PLOS ONE.

"This is the first study to show that the personality traits of listeners/readers have an effect on the interpretation of language," said the study's lead author Julie Boland, professor of linguistics and psychology at the University of Michigan in the US.

"In this experiment, we examined the social judgments that readers made about the writers," Boland noted. 

Eighty three participants read email responses to an ad for a housemate that either contained no errors or had been altered to include either typos, such as mkae (make) or abuot (about), or grammar errors, such as to/too, it's/its or your/you're. 

They rated the email writers in terms of perceived intelligence, friendliness and other attributes, as well as provided information about themselves.

At the end of the experiment, participants were asked if they noticed any grammatical errors in the responses. If they answered "yes," they indicated how much the errors bothered them.

As expected, participants who reported grammar being important at the beginning of the experiment were more likely to be bothered by grammatical errors at the end, study co-author Robin Queen from the University of Michigan said..

In addition, less agreeable people are more sensitive to grammatical errors, while more conscientious and less open people are sensitive to typos, the researchers said.​

​Abu Dhabi, April 5 (IANS/WAM) Abu Dhabi-based investment company Reem Investments has announced a net profit of $57.4 million for the financial year 2015.

The company's board of directors approved the 12 percent cash dividend -- an increase of 20 percent over the 2014 dividend.

Macau, April 6 (IANS) In a biggest ever launch in 10 years, HP Inc on Wednesday launched an aggressive, New Age portfolio of business printers with a focus on enhanced data security, faster and low-cost printing and energy savings. The game changer among 15 newly launched printers that include OfficeJet Pro and LaserJet devices is HP PageWide Technology -- a reliable and scalable print technology that has so far delivered more than 140 billion high-quality digital pages including large format printers and web presses. "We are reinventing printing for every business, whether they are small and midsize business (SMB) who need to be more productive and secure at an affordable price-point or organisations grappling with the fast evolving security risks in their complex network," Richard Bailey, president, Asia Pacific and Japan, HP Inc, told reporters here. The new HP PageWide printers -- which included HP PageWide Enterprise Colour 556 and HP PageWide Enterprise Colour MFP 586 devices -- will provide professional colour, best-in-class ownership cost, faster speed, best energy efficiency and the world's most advanced security and management features. The PageWide printers are designed for small businesses and medium-sized firms, printing up to 15,000 pages a month with a print speed of up to 75 pages per minute. While HP PageWide Enterprise Colour MFP 586 is expected to be available in May starting at Rs.150,000, HP PageWide Enterprise Colour 556 printer is expected to be available also in May starting at Rs.71,400. The HP PageWide Pro 500 series includes HP PageWide Pro 552dw and HP PageWide Pro MFP 577dw. The 552dw and 577dw are designed for small businesses and work groups printing up to 6,000 pages a month, with print speeds of up to 70 pages per minute. The PageWide Pro 500 series is expected to be available in India in May beginning at Rs.51,600. The HP PageWide Pro 400 series includes the HP PageWide Pro 452dw and the HP PageWide Pro MFP 477dw. These printers are designed for small businesses and work groups printing up to 4,500 pages a month with print speeds of up to 55 pages per minute. The PageWide 400 series is also expected to be available in India in May, starting at Rs.45,580. For micro and small businesses printing up to 2,000 pages a month, the HP OfficeJet Pro 8710/8720/8730/8740 all-in-one printers and HP OfficeJet Pro 8210 printer provide professional quality printing at up to 50 percent lower cost per page than lasers. While OfficeJet Pro 8700 series is to be available starting at Rs.19,252 in May, OfficeJet Pro 8210 is expected to be available at Rs.11,561. For micro and home businesses printing up to 800 pages a month, the HP OfficeJet Pro 6960/6970 all-in-one printers provide professional-quality printing at less than half the cost of laser printing. The OfficeJet Pro 6900 series is expected to be available in July starting at Rs.12,999. In addition to A4 devices, HP will soon expand the reach of PageWide technology to a new portfolio of A3 multi-function printers (MFPs). The company also launched a new "Secure Managed Print Services". "HP Secure Managed Print Services is to help customers secure their print environment with the strongest protection available in the industry," HP Inc said. The new HP PageWide business portfolio will be available through channel partners and at select retail store. "In addition, the new portfolio increases the number of managed devices designed for contractual channel partners and managed print services engagements," the company added. The HP OfficeJet Pro 8000 series features HP "Print Forward Designa to provide customers productivity with high speeds in a space-saving design that helps preserve office real estate." These new printers also include enhanced manageability and security features as well as seamless mobile printing. The new LaserJet products include original HP toner cartridges with JetIntelligence technology, enabling the industry's most advanced laser printing platform that offer leaner, faster, smarter options to help customers accelerate their business. HP JetAdvantage Private Print also features support for HP Common Card Reader for fast authentication.​

​Washington, April 6 (IANS) US President Barack Obama has called on Congress to reform the business tax system to close the loophole that allows for a financial practice known as corporate inversions.